ea0077p40 | Metabolism, Obesity and Diabetes | SFEBES2021
Ajjan Ramzi
, Hensor Elizabeth
, Shams Kave
, Galdo Francesco Del
, Abbas Afroze
, Woods Janet
, Fairclough Rebecca
, Pegg Lindsay
, Freeman Adrian
, Morgan Ann
, Stewart Paul
, Taylor Angela
, Arlt Wiebke
, Tahrani Abd
, Russell David
, Tiganescu Ana
Chronic wounds (e.g. diabetic foot ulcers) have a major impact on quality of life, yet treatments remain limited. Glucocorticoids impair wound healing; preclinical research suggests that blocking glucocorticoid activation by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) improves wound repair. This investigator-initiated double-blind, randomised, placebo-controlled parallel-group phase 2b pilot trial investigated efficacy, safety and feasibility of 11&...